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Issue 11, 2006
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Synthesis of the bicyclic core of tagetitoxin

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A synthesis of the 9-oxa-3-thiabicyclo[3.3.1]nonane ring system, which constitutes the core of the RNA polymerase inhibitor tagetitoxin, has been achieved through cyclisation of a thiol onto an electrophilic ketone.

Graphical abstract: Synthesis of the bicyclic core of tagetitoxin

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Publication details

The article was received on 19 Jan 2006, accepted on 31 Jan 2006 and first published on 14 Feb 2006

Article type: Communication
DOI: 10.1039/B600819D
Citation: Chem. Commun., 2006, 1197-1199
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    Synthesis of the bicyclic core of tagetitoxin

    J. R. H. Plet and M. J. Porter, Chem. Commun., 2006, 1197
    DOI: 10.1039/B600819D

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