Jump to main content
Jump to site search

Issue 13, 2006
Previous Article Next Article

Contra-Friedel–Crafts tert-butylation of substituted aromatic rings via directed metallation and sulfinylation

Author affiliations

Abstract

Directed metallation and sulfinylation yields sulfoxides which undergo ipso nucleophilic aromatic substitution with tertiary and secondary alkyllithiums, giving aromatic rings bearing alkyl groups generally incompatible with directed metallation methods and with regioselectivity complementary with classical Friedel–Crafts substitution.

Graphical abstract: Contra-Friedel–Crafts tert-butylation of substituted aromatic rings via directed metallation and sulfinylation

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Jan 2006, accepted on 02 Feb 2006 and first published on 21 Feb 2006


Article type: Communication
DOI: 10.1039/B600181E
Citation: Chem. Commun., 2006,0, 1393-1394
  •   Request permissions

    Contra-Friedel–Crafts tert-butylation of substituted aromatic rings via directed metallation and sulfinylation

    J. Clayden, C. C. Stimson and M. Keenan, Chem. Commun., 2006, 0, 1393
    DOI: 10.1039/B600181E

Search articles by author

Spotlight

Advertisements