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Issue 11, 2006
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Strong and selective binding of amiloride to thymine base opposite AP sites in DNA duplexes: simultaneous binding to DNA phosphate backbone

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Abstract

Amiloride (N-amidino-3,5-diamino-6-chloro-pyrazinecarboxamide hydrochloride) has two sets of hydrogen-bond forming sites suitable for target nucleotides and the phosphodiester DNA backbone by which a thymine base opposite an abasic site in DNA duplexes can be recognized with high selectivity and affinity, and it is applicable to the fluorescence detection of thymidine-related SNPs (single-nucleotide polymorphisms) of PCR amplification products.

Graphical abstract: Strong and selective binding of amiloride to thymine base opposite AP sites in DNA duplexes: simultaneous binding to DNA phosphate backbone

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Publication details

The article was received on 22 Nov 2005, accepted on 12 Jan 2006 and first published on 30 Jan 2006


Article type: Communication
DOI: 10.1039/B516575J
Citation: Chem. Commun., 2006,0, 1185-1187
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    Strong and selective binding of amiloride to thymine base opposite AP sites in DNA duplexes: simultaneous binding to DNA phosphate backbone

    C. Zhao, Q. Dai, T. Seino, Y. Cui, S. Nishizawa and N. Teramae, Chem. Commun., 2006, 0, 1185
    DOI: 10.1039/B516575J

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