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Issue 48, 2006
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Enhancement of RNA cleavage activity of 10–23 DNAzyme by covalently introduced intercalator

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Abstract

By introducing an intercalator through D-threoninol to the 10–23 DNAzyme at the junction between its catalytic loop and the binding arm, the RNA cleavage activity was greatly improved.

Graphical abstract: Enhancement of RNA cleavage activity of 10–23 DNAzyme by covalently introduced intercalator

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Publication details

The article was received on 01 Aug 2006, accepted on 27 Sep 2006 and first published on 13 Oct 2006


Article type: Communication
DOI: 10.1039/B611078A
Citation: Chem. Commun., 2006,0, 5062-5064
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    Enhancement of RNA cleavage activity of 10–23 DNAzyme by covalently introduced intercalator

    H. Asanuma, H. Hayashi, J. Zhao, X. Liang, A. Yamazawa, T. Kuramochi, D. Matsunaga, Y. Aiba, H. Kashida and M. Komiyama, Chem. Commun., 2006, 0, 5062
    DOI: 10.1039/B611078A

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