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Issue 46, 2006
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A new consecutive three-component oxazole synthesis by an amidation–coupling–cycloisomerization (ACCI) sequence

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Abstract

A novel consecutive three-component synthesis of 1-(hetero)aryl-2-(2-(hetero)aryl-oxazol-5-yl) ethanones starting from propargyl amine and acid chlorides, both for amidation and cross-coupling, is based upon an amidation–coupling–cycloisomerization (ACCI) sequence.

Graphical abstract: A new consecutive three-component oxazole synthesis by an amidation–coupling–cycloisomerization (ACCI) sequence

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Publication details

The article was received on 27 Jul 2006, accepted on 12 Sep 2006 and first published on 29 Sep 2006


Article type: Communication
DOI: 10.1039/B610839C
Citation: Chem. Commun., 2006,0, 4817-4819
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    A new consecutive three-component oxazole synthesis by an amidation–coupling–cycloisomerization (ACCI) sequence

    E. Merkul and T. J. J. Müller, Chem. Commun., 2006, 0, 4817
    DOI: 10.1039/B610839C

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