“Click” synthesis of small molecule probes for activity-based fingerprinting of matrix metalloproteases

Jun Wang; Mahesh Uttamchandani; Junqi Li; Mingyu Hu; Shao Q. Yao

doi:10.1039/B609446E

“Click” synthesis of small molecule probes for activity-based fingerprinting of matrix metalloproteases

Jun Wang,^a Mahesh Uttamchandani,^b Junqi Li,^a Mingyu Hu^a and Shao Q. Yao*^a^b^c

* Corresponding authors

^a Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543
E-mail: chmyaosq@nus.edu.sg
Fax: (+65) 67791691
Tel: (+65) 68741683

^b Department of Biological Sciences, National University of Singapore, Singapore 117543

^c NUS MedChem Program of the Office of Life Sciences, National University of Singapore, Singapore 117543

Abstract

By using “Click Chemistry”, we achieved the facile synthesis of various affinity-based hydroxamate probes that enable generation of activity-based fingerprints of a variety of metalloproteases, including matrix metalloproteases (MMPs), in proteomics experiments.

Supplementary files

Publication details

The article was received on 04 Jul 2006, accepted on 02 Aug 2006 and first published on 15 Aug 2006

Article type: Communication

DOI: 10.1039/B609446E

Citation: Chem. Commun., 2006,0, 3783-3785

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“Click” synthesis of small molecule probes for activity-based fingerprinting of matrix metalloproteases

J. Wang, M. Uttamchandani, J. Li, M. Hu and S. Q. Yao, Chem. Commun., 2006, 0, 3783
DOI: 10.1039/B609446E
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Chemical Communications

“Click” synthesis of small molecule probes for activity-based fingerprinting of matrix metalloproteases

Abstract

Supplementary files

Publication details

“Click” synthesis of small molecule probes for activity-based fingerprinting of matrix metalloproteases

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