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Issue 22, 2006
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The structure of nanotubes formed by diphenylalanine, the core recognition motif of Alzheimer's β-amyloid polypeptide

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Abstract

Alzheimer's β-amyloid diphenylalanine motif has previously been shown to self-assemble into discrete and extraordinary stiff nanotubes; these nanotubes were initially thought to be distinct from the single crystal structure of diphenylalanine, but it is now shown that the X-ray powder diffraction pattern of the nanotubes is identical to the simulated pattern for the single crystal structure, affording a new foundation for understanding and rationalizing the properties of this remarkable organic material.

Graphical abstract: The structure of nanotubes formed by diphenylalanine, the core recognition motif of Alzheimer's β-amyloid polypeptide

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Publication details

The article was received on 01 Mar 2006, accepted on 30 Mar 2006 and first published on 13 Apr 2006


Article type: Communication
DOI: 10.1039/B603080G
Citation: Chem. Commun., 2006, 2332-2334
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    The structure of nanotubes formed by diphenylalanine, the core recognition motif of Alzheimer's β-amyloid polypeptide

    C. H. Görbitz, Chem. Commun., 2006, 2332
    DOI: 10.1039/B603080G

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