Issue 3, 2006
From the journal:

Chemical Communications

The Morita–Baylis–Hillman adducts of β-aryl nitroethylenes with other activated alkenes: synthesis and anticancer activity studies†‡

Mamta Dadwal,a   Renu Mohan,b   Dulal Panda,*b   Shaikh M. Mobinc  and  Irishi N. N. Namboothiri*a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Technology, Bombay, India
E-mail: irishi@iitb.ac.in
Fax: +91-22-2576-7152
Tel: + 91-22-2576-7196

b School of Biosciences and Bioengineering, Indian Institute of Technology, Bombay, India
E-mail: panda@btc.iitb.ac.in
Fax: +91-22-2572-3480
Tel: + 91-22-2576-7838

c National Single Crystal X-ray Diffraction Facility, Indian Institute of Technology, Bombay, India

Abstract

The Morita–Baylis–Hillman (MBH) adducts of β-aryl nitroethylenes with methyl vinyl ketone (MVK) and acrylate, formed in moderate to good yield when mediated by imidazole/LiCl in THF at room temperature, inhibit HeLa cell proliferation by binding to tubulin.

Graphical abstract: The Morita–Baylis–Hillman adducts of β-aryl nitroethylenes with other activated alkenes: synthesis and anticancer activity studies

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Article information

DOI
https://doi.org/10.1039/B512267H
Article type
Communication
Submitted
30 Aug 2005
Accepted
18 Oct 2005
First published
21 Nov 2005

Chem. Commun., 2006, 338-340

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The Morita–Baylis–Hillman adducts of β-aryl nitroethylenes with other activated alkenes: synthesis and anticancer activity studies

M. Dadwal, R. Mohan, D. Panda, S. M. Mobin and I. N. N. Namboothiri, Chem. Commun., 2006, 338 DOI: 10.1039/B512267H

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