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Issue 3, 2006
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Affinity prediction for substrates of the peptide transporter PepT1

Patrick D. Bailey,*a  C. A. Richard Boyd,b  Ian D. Collier,c  John. P. George,c  George L. Kellett,d  David Meredith,b  Keith M. Morgan,c  Rachel Pettecrewa  and  Richard A. Pricea 
Author affiliations

* Corresponding authors

a School of Chemistry, Faraday Building, The University of Manchester, Sackville Street, Manchester, UK
E-mail: pat.bailey@manchester.ac.uk
Fax: +44 (0)161 306 4541
Tel: +44 (0)161 306 4448

b Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK
E-mail: richard.boyd@anat.ox.ac.uk
Fax: +44 (0)1865 272 420
Tel: +44 (0)1865 272 169

c School of EPS – Chemistry, Perkin Building, Heriot-Watt University, Edinburgh, UK
E-mail: k.m.morgan@hw.ac.uk
Fax: +44 (0)131 451 3180
Tel: +44 (0)131 451 8020

d Department of Biology, University of York, PO Box 373, York, UK
E-mail: glk1@york.ac.uk
Fax: +44 (0)1904 328 505
Tel: +44 (0)1904 328 500

Abstract

A quantitative method has been developed for determining the affinity of substrates for the peptide transporter PepT1, allowing oral availability of drugs via PepT1 to be estimated.

Graphical abstract: Affinity prediction for substrates of the peptide transporter PepT1

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Publication details

The article was received on 25 Aug 2005, accepted on 27 Oct 2005 and first published on 30 Nov 2005


Article type: Communication
DOI: 10.1039/B511996K
Citation: Chem. Commun., 2006,0, 323-325
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    Affinity prediction for substrates of the peptide transporter PepT1

    P. D. Bailey, C. A. R. Boyd, I. D. Collier, John. P. George, G. L. Kellett, D. Meredith, K. M. Morgan, R. Pettecrew and R. A. Price, Chem. Commun., 2006, 0, 323
    DOI: 10.1039/B511996K

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