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Issue 22, 2005
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Probing dipeptide trans/cis stereochemistry using pH control of thiopeptide analogues, and application to the PepT1 transporter

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Abstract

The stereochemistry of thiodipeptides of proline [e.g. Ala-Ψ[CS-N]-Pro] can be controlled using pH, allowing the trans-preference for substrates of the peptide transporter PepT1 to be confirmed.

Graphical abstract: Probing dipeptide trans/cis stereochemistry using pH control of thiopeptide analogues, and application to the PepT1 transporter

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Publication details

The article was received on 19 Sep 2005, accepted on 19 Sep 2005 and first published on 07 Oct 2005


Article type: Communication
DOI: 10.1039/B513274F
Citation: Org. Biomol. Chem., 2005,3, 4038-4039
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    Probing dipeptide trans/cis stereochemistry using pH control of thiopeptide analogues, and application to the PepT1 transporter

    P. D. Bailey, C. A. R. Boyd, I. D. Collier, G. L. Kellett, D. Meredith, K. M. Morgan, R. Pettecrew and R. A. Price, Org. Biomol. Chem., 2005, 3, 4038
    DOI: 10.1039/B513274F

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