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Issue 24, 2005
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Structure–activity relationship studies on CXCR4 antagonists having cyclic pentapeptide scaffolds

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Abstract

Structure–activity relationship studies on CXCR4 antagonists, which were previously found by using cyclic pentapeptide libraries, were performed to optimize side-chain functional groups, involving conformationally constrained analogues. In addition, a new lead of cyclic pentapeptides with the introduction of a novel pharmacophore was developed.

Graphical abstract: Structure–activity relationship studies on CXCR4 antagonists having cyclic pentapeptide scaffolds

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Publication details

The article was received on 19 Sep 2005, accepted on 26 Oct 2005 and first published on 15 Nov 2005


Article type: Paper
DOI: 10.1039/B513145F
Citation: Org. Biomol. Chem., 2005,3, 4392-4394
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    Structure–activity relationship studies on CXCR4 antagonists having cyclic pentapeptide scaffolds

    H. Tamamura, A. Esaka, T. Ogawa, T. Araki, S. Ueda, Z. Wang, J. O. Trent, H. Tsutsumi, H. Masuno, H. Nakashima, N. Yamamoto, S. C. Peiper, A. Otaka and N. Fujii, Org. Biomol. Chem., 2005, 3, 4392
    DOI: 10.1039/B513145F

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