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Issue 21, 2005
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Oligo- and poly-nucleotides: 50 years of chemical synthesis

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Abstract

It is fifty years since the first chemical synthesis of a dinucleoside phosphate and a dinucleotide with natural 3′→5′-internucleotide linkages was reported. The main developments in the methodology of oligo- and poly-nucleotide synthesis that have taken place since are described.

Graphical abstract: Oligo- and poly-nucleotides: 50 years of chemical synthesis

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Publication details

The article was received on 21 Jul 2005 and first published on 05 Oct 2005


Article type: Perspective
DOI: 10.1039/B510458K
Citation: Org. Biomol. Chem., 2005,3, 3851-3868
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    Oligo- and poly-nucleotides: 50 years of chemical synthesis

    C. B. Reese, Org. Biomol. Chem., 2005, 3, 3851
    DOI: 10.1039/B510458K

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