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Issue 21, 2005
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Synthesis of 5-acyl-6-[2-hydroxy-3-(amino)propylamino]-1,3-dialkyl-1H-pyrimidine-2,4-diones

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Abstract

A stepwise synthetic approach involving substitution of 6-chloro-1,3-dialkyluracils (5 and 6) with 3-(tert-amino)-2-hydroxypropylamines and subsequent acylation at C5 of uracil has been used to synthesize pyrimidinediones 27–33 in 61–89% overall yield. The conformational aspects of the new molecules based upon NMR data have been discussed.

Graphical abstract: Synthesis of 5-acyl-6-[2-hydroxy-3-(amino)propylamino]-1,3-dialkyl-1H-pyrimidine-2,4-diones

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Publication details

The article was received on 11 Jul 2005, accepted on 31 Aug 2005 and first published on 26 Sep 2005


Article type: Paper
DOI: 10.1039/B509775D
Citation: Org. Biomol. Chem., 2005,3, 3958-3965
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    Synthesis of 5-acyl-6-[2-hydroxy-3-(amino)propylamino]-1,3-dialkyl-1H-pyrimidine-2,4-diones

    P. Singh, K. Paul and W. Holzer, Org. Biomol. Chem., 2005, 3, 3958
    DOI: 10.1039/B509775D

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