Jump to main content
Jump to site search

Issue 16, 2005
Previous Article Next Article

The first synthesis and cytostatic activity of novel 6-(fluoromethyl)purine bases and nucleosides

Author affiliations

Abstract

Two alternative approaches to the synthesis of novel 6-(fluoromethyl)purine bases and nucleosides are described either by direct deoxyfluorination or by multistep functional group transformations starting from 6-(hydroxymethyl)purines. 6-(Fluoromethyl)purine ribonucleoside displayed significant cytostatic effects.

Graphical abstract: The first synthesis and cytostatic activity of novel 6-(fluoromethyl)purine bases and nucleosides

Back to tab navigation

Supplementary files

Publication details

The article was received on 08 Jun 2005, accepted on 09 Jun 2005 and first published on 04 Jul 2005


Article type: Paper
DOI: 10.1039/B508122J
Citation: Org. Biomol. Chem., 2005,3, 3001-3007
  •   Request permissions

    The first synthesis and cytostatic activity of novel 6-(fluoromethyl)purine bases and nucleosides

    P. Šilhár, R. Pohl, I. Votruba and M. Hocek, Org. Biomol. Chem., 2005, 3, 3001
    DOI: 10.1039/B508122J

Search articles by author

Spotlight

Advertisements