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Issue 20, 2005
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Synthesis of structures corresponding to the capsular polysaccharide of Neisseria meningitidis group A

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Abstract

Four differently substituted trimers of the CPS repeating unit have been synthesised in order to investigate the dependence on oligosaccharide size, acetylation and mode of phosphorylation of glycoconjugate vaccines against Neisseria meningitidis group A. A spacer-containing starting monomer, a H-phosphonate elongating monomer and a 6-O-phosphorylated H-phosphonate cap monomer have been synthesised and coupled together to afford, after deprotection, the target trimer structures differing in their acetylation and phosphorylation substitution pattern.

Graphical abstract: Synthesis of structures corresponding to the capsular polysaccharide of Neisseria meningitidis group A

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Publication details

The article was received on 06 Jun 2005, accepted on 23 Aug 2005 and first published on 13 Sep 2005


Article type: Paper
DOI: 10.1039/B507898A
Citation: Org. Biomol. Chem., 2005,3, 3782-3787
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    Synthesis of structures corresponding to the capsular polysaccharide of Neisseria meningitidis group A

    R. Slättegård, P. Teodorovic, H. Hadgu Kinfe, N. Ravenscroft, D. W. Gammon and S. Oscarson, Org. Biomol. Chem., 2005, 3, 3782
    DOI: 10.1039/B507898A

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