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Issue 17, 2005
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Rational design of new bifunctional inhibitors of type II dehydroquinase

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Abstract

Selective inhibitors of type II dehydroquinase were rationally designed to explore a second binding-pocket in the active-site. The molecular modelling, synthesis, inhibition studies and crystal structure determination are described.

Graphical abstract: Rational design of new bifunctional inhibitors of type II dehydroquinase

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Publication details

The article was received on 23 May 2005, accepted on 19 Jul 2005 and first published on 01 Aug 2005


Article type: Communication
DOI: 10.1039/B507156A
Citation: Org. Biomol. Chem., 2005,3, 3102-3104
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    Rational design of new bifunctional inhibitors of type II dehydroquinase

    M. D. Toscano, K. A. Stewart, J. R. Coggins, A. J. Lapthorn and C. Abell, Org. Biomol. Chem., 2005, 3, 3102
    DOI: 10.1039/B507156A

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