Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 16, 2005
Previous Article Next Article

Synthesis, isolation and characterisation of β-sitosterol and β-sitosterol oxide derivatives

Author affiliations

Abstract

β-Sitosterol is the most prevalent plant cholesterol derivative (phytosterol) and can undergo similar oxidation to cholesterol, leading to β-sitosterol oxides. The biological impact of phytosterol oxides has only been evaluated in a phytosterol blend (usually of β-sitosterol, campesterol, stigmasterol and dihydrobrassicasterol). The lack of pure phytosterols, including β-sitosterol, hinders the collection of significant toxicity data on the individual β-sitosterol oxides. An efficient synthetic route to multi-gram quantities of pure β-sitosterol is described here, together with the first syntheses and characterisation of pure β-sitosterol oxides.

Graphical abstract: Synthesis, isolation and characterisation of β-sitosterol and β-sitosterol oxide derivatives

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 12 Apr 2005, accepted on 14 Jun 2005 and first published on 13 Jul 2005


Article type: Paper
DOI: 10.1039/B505069C
Citation: Org. Biomol. Chem., 2005,3, 3059-3065
  •   Request permissions

    Synthesis, isolation and characterisation of β-sitosterol and β-sitosterol oxide derivatives

    F. O. McCarthy, J. Chopra, A. Ford, S. A. Hogan, J. P. Kerry, N. M. O'Brien, E. Ryan and A. R. Maguire, Org. Biomol. Chem., 2005, 3, 3059
    DOI: 10.1039/B505069C

Search articles by author