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Synthesis of screening substrates for the directed evolution of sialic acid aldolase: towards tailored enzymes for the preparation of influenza A sialidase inhibitor analogues

Thomas Woodhall,ab   Gavin Williams,bc   Alan Berrybc and   Adam Nelson*ab  
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a
School of Chemistry, University of Leeds, Leeds, UK
b
Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK
c
School of Biochemistry and Microbiology, University of Leeds, Leeds, UK
Org. Biomol. Chem., 2005,3, 1795-1800

DOI: 10.1039/B501503K
Received 31 Jan 2005, Accepted 15 Mar 2005
First published online 12 Apr 2005
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