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Issue 4, 2005
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Synthesis and photochemical properties of photoactivated antitumor prodrugs releasing 5-fluorouracil

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Abstract

A new family of antitumor prodrugs (1–3) of 5-fluorouracil (5-FU) possessing photolabile 2-nitrobenzyl chromophores have been designed and synthesized to investigate the efficiency and mechanism of photoactivated 5-FU release upon UV-irradiation at λex = 365 nm. The photoactivated prodrug 3 derived from conjugation of 2 with a tumor-homing cyclic peptide Cys-Asn-Gly-Arg-Cys (CNGRC) was so designed as to manifest a tumor-targeting function.

Graphical abstract: Synthesis and photochemical properties of photoactivated antitumor prodrugs releasing 5-fluorouracil

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Publication details

The article was received on 24 Nov 2004, accepted on 20 Dec 2004 and first published on 12 Jan 2005


Article type: Paper
DOI: 10.1039/B417734G
Citation: Org. Biomol. Chem., 2005,3, 592-596
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    Synthesis and photochemical properties of photoactivated antitumor prodrugs releasing 5-fluorouracil

    Z. Zhang, H. Hatta, T. Ito and S. Nishimoto, Org. Biomol. Chem., 2005, 3, 592
    DOI: 10.1039/B417734G

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