Issue 14, 2005
From the journal:

Organic & Biomolecular Chemistry

Enzyme-cleavable linkers for peptide and glycopeptide synthesis

Beatrice A. Maltman,a   Mallesham Bejugama  and  Sabine L. Flitsch*a  

* Corresponding authors

a School of Chemistry, Edinburgh University, Kings Buildings, West Mains Road, Edinburgh, UK
E-mail: Sabine.Flitsch@manchester.ac.uk
Fax: 01316504719
Tel: 01316504719

Abstract

Hydroxymethylphenoxy linkers that are commonly used in solid phase peptide synthesis are surprisingly susceptible to efficient cleavage by the protease chymotrypsin with a broad range of amino acid residues being tolerated at the scissile bond; this enzyme-cleavable linker system has been applied to peptide and glycopeptide synthesis.

Graphical abstract: Enzyme-cleavable linkers for peptide and glycopeptide synthesis

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Article information

DOI
https://doi.org/10.1039/B506154G
Article type
Communication
Submitted
03 May 2005
Accepted
31 May 2005
First published
16 Jun 2005

Org. Biomol. Chem., 2005,3, 2505-2507

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Enzyme-cleavable linkers for peptide and glycopeptide synthesis

B. A. Maltman, M. Bejugam and S. L. Flitsch, Org. Biomol. Chem., 2005, 3, 2505 DOI: 10.1039/B506154G

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