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Issue 7, 2005
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New aminocyclitols as modulators of glucosylceramide metabolism

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Abstract

A series of 13 aminocyclitol derivatives belonging to two different families is described. Their configuration is governed by the regio- and stereocontrolled epoxide opening of a suitably protected conduritol-B epoxide. Studies on several glycosyl processing enzymes indicate that some of them are good inhibitors of glucosylceramide hydrolase. A rationale to account for preliminary structure–activity relationships is provided.

Graphical abstract: New aminocyclitols as modulators of glucosylceramide metabolism

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Publication details

The article was received on 27 Jul 2004, accepted on 12 Jan 2005 and first published on 01 Mar 2005


Article type: Paper
DOI: 10.1039/B411473F
Citation: Org. Biomol. Chem., 2005,3, 1195-1201
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    New aminocyclitols as modulators of glucosylceramide metabolism

    M. Egido-Gabás, P. Serrano, J. Casas, A. Llebaria and A. Delgado, Org. Biomol. Chem., 2005, 3, 1195
    DOI: 10.1039/B411473F

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