A short stereoselective synthesis of the Fusarium toxin equisetin, a potent inhibitor of HIV-1 integrase enzyme is described, using as the key step a stereoselective intramolecular Diels–Alder reaction of a fully conjugated E,E,E-triene with a trisubstituted γ,δ-unsaturated β-ketothioester.
L. T. Burke, D. J. Dixon, S. V. Ley and F. Rodríguez, Org. Biomol. Chem., 2005, 3, 274 DOI: 10.1039/B411350K
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