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Issue 9, 2005
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Does it bind? An instant binding assay for DNA oligonucleotide interactive small molecules

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Abstract

Ultrafiltration analysis has been used to screen DNA oligonucleotide interactive small molecules for the first time, providing an almost instantaneous indication of the binding affinity, and was used to identify a new class of DNA interactive molecules based on a range of dihydro-imidazo-phenanthridinium-based framework; this methodology provides a straightforward yes/no answer to small molecule DNA binding.

Graphical abstract: Does it bind? An instant binding assay for DNA oligonucleotide interactive small molecules

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Publication details

The article was received on 19 May 2005, accepted on 11 Jul 2005 and first published on 25 Jul 2005


Article type: Letter
DOI: 10.1039/B507037F
Citation: New J. Chem., 2005,29, 1118-1120
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    Does it bind? An instant binding assay for DNA oligonucleotide interactive small molecules

    L. V. Smith, J. M. de la Fuente, K. M. Guthrie, A. D. C. Parenty and L. Cronin, New J. Chem., 2005, 29, 1118
    DOI: 10.1039/B507037F

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