Issue 3, 2005
From the journal:

Molecular BioSystems

Nucleoside phosphocholine amphiphile for in vitro DNA transfection†

Louis Moreau,a   Philippe Barthélémy,*a   Yougen Li,b   Dan Luo,b   Carla A. H. Pratac  and  Mark W. Grinstaffc  

* Corresponding authors

a Faculté des sciences d'Avignon 33, rue Louis Pasteur, Avignon, France
E-mail: philippe.barthelemy@univ-avignon.fr
Fax: 33 4 90 14 44 41
Tel: 33 4 90 14 44 65

b Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY 14853, USA

c Departments of Biomedical Engineering and Chemistry, Boston University, Boston, MA 02215, USA

Abstract

A new transfection reagent based on nucleoside phosphocholine amphiphile leading to high transfection efficacy and low cytotoxicity is described. TEM, ethidium bromide displacement assays, agarose gel electrophoresis and SAXS studies support the formation of lipoplexes for the transfection of CHO cells.

Graphical abstract: Nucleoside phosphocholine amphiphile for in vitro DNA transfection

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Article information

DOI
https://doi.org/10.1039/B503302K
Article type
Paper
Submitted
08 Mar 2005
Accepted
30 Jun 2005
First published
22 Jul 2005

Mol. BioSyst., 2005,1, 260-264

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Nucleoside phosphocholine amphiphile for in vitro DNA transfection

L. Moreau, P. Barthélémy, Y. Li, D. Luo, C. A. H. Prata and M. W. Grinstaff, Mol. BioSyst., 2005, 1, 260 DOI: 10.1039/B503302K

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