Jump to main content
Jump to site search

Issue 11, 2005
Previous Article Next Article

Hydrodynamic filtration for on-chip particle concentration and classification utilizing microfluidics

Author affiliations

Abstract

We propose here a new method for continuous concentration and classification of particles in microfluidic devices, named hydrodynamic filtration. When a particle is flowing in a microchannel, the center position of the particle cannot be present in a certain distance from sidewalls, which is equal to the particle radius. The proposed method utilizes this fact, and is performed using a microchannel having multiple side branch channels. By withdrawing a small amount of liquid repeatedly from the main stream through the side channels, particles are concentrated and aligned onto the sidewalls. Then the concentrated and aligned particles can be collected according to size through other side channels (selection channels) in the downstream of the microchannel. Therefore, continuous introduction of a particle suspension into the microchannel enables both particle concentration and classification at the same time. In this method, the flow profile inside a precisely fabricated microchannel determines the size limit of the filtered substances. So the filtration can be performed even when the channel widths are much larger than the particle size, without the problem of channel clogging. In this study, concentrations of polymer microspheres with diameters of 1–3 µm were increased 20–50-fold, and they were collected independently according to size. In addition, selective enrichment of leukocytes from blood was successfully performed.

Graphical abstract: Hydrodynamic filtration for on-chip particle concentration and classification utilizing microfluidics

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 Jul 2005, accepted on 26 Aug 2005 and first published on 26 Sep 2005


Article type: Paper
DOI: 10.1039/B509386D
Citation: Lab Chip, 2005,5, 1233-1239
  •   Request permissions

    Hydrodynamic filtration for on-chip particle concentration and classification utilizing microfluidics

    M. Yamada and M. Seki, Lab Chip, 2005, 5, 1233
    DOI: 10.1039/B509386D

Search articles by author

Spotlight

Advertisements