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Issue 12, 2005
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Bio-sensing on a chip with compact discs and nanofibers

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Abstract

This paper describes a novel, sensitive detection system for biomolecules (DNA and proteins etc.) that is integrated in a lab-on-a-chip utilizing optical compact discs (CDs) and bio-nanofibers. The new method comprises a microchannel containing CD grating that confines fragments of unique bacterial cellulose fibrils (BC), which have nanometre scale fibers and holes. A maximum of six times higher sensitivity to detect DNA was obtained with this CD and BC system compared to a conventional method. We also demonstrate an effective light-confining effect for biological application with the new method.

Graphical abstract: Bio-sensing on a chip with compact discs and nanofibers

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Publication details

The article was received on 31 May 2005, accepted on 01 Sep 2005 and first published on 02 Nov 2005


Article type: Technical Note
DOI: 10.1039/B507637D
Citation: Lab Chip, 2005,5, 1412-1415
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    Bio-sensing on a chip with compact discs and nanofibers

    M. Tabuchi, K. Kobayashi, M. Fujimoto and Y. Baba, Lab Chip, 2005, 5, 1412
    DOI: 10.1039/B507637D

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