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Issue 10, 2005
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An integrated microfluidic device for influenza and other genetic analyses

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Abstract

An integrated microfluidic device capable of performing a variety of genetic assays has been developed as a step towards building systems for widespread dissemination. The device integrates fluidic and thermal components such as heaters, temperature sensors, and addressable valves to control two nanoliter reactors in series followed by an electrophoretic separation. This combination of components is suitable for a variety of genetic analyses. As an example, we have successfully identified sequence-specific hemagglutinin A subtype for the A/LA/1/87 strain of influenza virus. The device uses a compact design and mass production technologies, making it an attractive platform for a variety of widely disseminated applications.

Graphical abstract: An integrated microfluidic device for influenza and other genetic analyses

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Publication details

The article was received on 04 May 2005, accepted on 22 Jul 2005 and first published on 18 Aug 2005


Article type: Paper
DOI: 10.1039/B505994A
Citation: Lab Chip, 2005,5, 1024-1032
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    An integrated microfluidic device for influenza and other genetic analyses

    R. Pal, M. Yang, R. Lin, B. N. Johnson, N. Srivastava, S. Z. Razzacki, K. J. Chomistek, D. C. Heldsinger, R. M. Haque, V. M. Ugaz, P. K. Thwar, Z. Chen, K. Alfano, M. B. Yim, M. Krishnan, A. O. Fuller, R. G. Larson, D. T. Burke and M. A. Burns, Lab Chip, 2005, 5, 1024
    DOI: 10.1039/B505994A

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