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Issue 6, 2005
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Assembly of multicellular constructs and microarrays of cells using magnetic nanowires

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Abstract

An approach is described for controlling the spatial organization of mammalian cells using ferromagnetic nanowires in conjunction with patterned micromagnet arrays. The nanowires are fabricated by electrodeposition in nanoporous templates, which allows for precise control of their size and magnetic properties. The high aspect ratio and large remanent magnetization of the nanowires enable suspensions of cells bound to Ni nanowires to be controlled with low magnetic fields. This was used to produce one- and two-dimensional field-tuned patterning of suspended 3T3 mouse fibroblasts. Self-assembled one-dimensional chains of cells were obtained through manipulation of the wires' dipolar interactions. Ordered patterns of individual cells in two dimensions were formed through trapping onto magnetic microarrays of ellipsoidal permalloy micromagnets. Cell chains were formed on the arrays by varying the spacing between the micromagnets or the strength of fluid flow over the arrays. The positioning of cells on the array was further controlled by varying the direction of an external magnetic field. These results demonstrate the possibility of using magnetic nanowires to organize cells.

Graphical abstract: Assembly of multicellular constructs and microarrays of cells using magnetic nanowires

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Publication details

The article was received on 17 Jan 2005, accepted on 21 Apr 2005 and first published on 13 May 2005


Article type: Paper
DOI: 10.1039/B500243E
Citation: Lab Chip, 2005,5, 598-605
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    Assembly of multicellular constructs and microarrays of cells using magnetic nanowires

    M. Tanase, E. J. Felton, D. S. Gray, A. Hultgren, C. S. Chen and D. H. Reich, Lab Chip, 2005, 5, 598
    DOI: 10.1039/B500243E

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