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Issue 5, 2005
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Batch-mode mixing on centrifugal microfluidic platforms

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Abstract

We present two novel fluidic concepts to drastically accelerate the process of mixing in batch-mode (stopped-flow) on centrifugal microfluidic platforms. The core of our simple and robust setup exhibits a microstructured disk with a round mixing chamber rotating on a macroscopic drive unit. In the first approach, magnetic beads which are prefilled into the mixing chamber are periodically deflected by a set of permanent magnets equidistantly aligned at spatially fixed positions in the lab-frame. Their radial positions alternatingly deviate by a slight positive and negative offset from the mean orbit of the chamber to periodically deflect the beads inbound and outbound during rotation. Advection is induced by the relative motion of the beads with respect to the liquid which results from the magnetic and centrifugal forces, as well as inertia. In a second approach—without magnetic beads—the disk is spun upon periodic changes in the sense of rotation. This way, inertia effects induce stirring of the liquids. As a result, both strategies accelerate mixing from about 7 minutes for mere diffusion to less than five seconds. Combining both effects, an ultimate mixing time of less than one second could be achieved.

Graphical abstract: Batch-mode mixing on centrifugal microfluidic platforms

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Publication details

The article was received on 03 Feb 2005, accepted on 16 Mar 2005 and first published on 07 Apr 2005


Article type: Technical Note
DOI: 10.1039/B418253G
Citation: Lab Chip, 2005,5, 560-565
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    Batch-mode mixing on centrifugal microfluidic platforms

    M. Grumann, A. Geipel, L. Riegger, R. Zengerle and J. Ducrée, Lab Chip, 2005, 5, 560
    DOI: 10.1039/B418253G

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