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Issue 4, 2005
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Dynamics of capillary flow of blood into a microfluidic channel

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Abstract

In this paper, a novel mathematical approach is devised to analyze the flow of blood from a droplet into a microcapillary channel. Special attention is devoted to estimate the effects of variable hydraulic resistance over different flow regimes, influence of suspended RBC particulates on the non-Newtonian flow characteristics and implications of a dynamically-evolving contact angle. Flow characteristics depicting advancement of the fluid within the microfluidic channel turn out to be typically non-linear, as per relative instantaneous strengths of the capillary forces and viscous resistances. It is found that the greater the ‘pseudoplasticity’ of the blood, the weaker the retarding shear forces. The driving forces, on the other hand, become stronger with time, on account of a reduction of contact angle with a decrease of blood flow velocity, although this strengthening is less prominent for blood samples with greater ‘pseudoplasticity’. It is revealed that RBCs suspended in blood samples have a strong influence on the effective blood viscosity, and consequently, may drive the fluid significantly faster into the microchannel, especially when the characteristic length scales of the suspensions approach the hydraulic radius of the channel.

Graphical abstract: Dynamics of capillary flow of blood into a microfluidic channel

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Publication details

The article was received on 20 Sep 2004, accepted on 10 Jan 2005 and first published on 03 Feb 2005


Article type: Paper
DOI: 10.1039/B414566F
Citation: Lab Chip, 2005,5, 421-430
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    Dynamics of capillary flow of blood into a microfluidic channel

    S. Chakraborty, Lab Chip, 2005, 5, 421
    DOI: 10.1039/B414566F

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