A microfluidic electroporation device for cell lysis

Hang Lu; Martin A. Schmidt; Klavs F. Jensen

doi:10.1039/B406205A

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Lab on a Chip

Issue 1, 2005

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A microfluidic electroporation device for cell lysis

Hang Lu , Martin A. Schmidt and Klavs F. Jensen

Lab Chip, 2005, 5, 23-29

DOI: 10.1039/B406205A
Received 26 Apr 2004, Accepted 30 Jul 2004
First published on the web 05 Nov 2004

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We demonstrate a micro-electroporation device for cell lysis prior to subcellular analysis. Simple circuit models show that electrical lysis method is advantageous because it is selective towards plasma membrane while leaving organelle membrane undamaged. In addition, miniaturization of this concept leads to negligible heat generation and bubble formation. The designed microdevices were fabricated using a combination of photolithography, metal-film deposition, and electroplating. We demonstrate the electro-lysis of human carcinoma cells in these devices to release the subcellular materials.

Abstract from Analytical Abstracts 2005

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