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Issue 1, 2005
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A microfluidic electroporation device for cell lysis

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Abstract

We demonstrate a micro-electroporation device for cell lysis prior to subcellular analysis. Simple circuit models show that electrical lysis method is advantageous because it is selective towards plasma membrane while leaving organelle membrane undamaged. In addition, miniaturization of this concept leads to negligible heat generation and bubble formation. The designed microdevices were fabricated using a combination of photolithography, metal-film deposition, and electroplating. We demonstrate the electro-lysis of human carcinoma cells in these devices to release the subcellular materials.

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Publication details

The article was received on 26 Apr 2004, accepted on 30 Jul 2004 and first published on 05 Nov 2004


Article type: Paper
DOI: 10.1039/B406205A
Citation: Lab Chip, 2005,5, 23-29
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    A microfluidic electroporation device for cell lysis

    H. Lu, M. A. Schmidt and K. F. Jensen, Lab Chip, 2005, 5, 23
    DOI: 10.1039/B406205A

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