Jump to main content
Jump to site search

Issue 42, 2005
Previous Article Next Article

Encapsulation of pyrene within self-assembled peptide amphiphile nanofibers

Author affiliations

Abstract

Certain peptide amphiphiles (PAs) in aqueous media are known to form high-aspect-ratio cylindrical nanofibers with hydrophobic cores. Using cholesterol or palmitic acid as the hydrophobe and the biological adhesion epitope RGDS as the hydrophilic segment, we studied the encapsulation of pyrene, a small hydrophobic molecule, within the cores of the self-assembling PA nanofibers. Circular dichroism (CD), transmission electron microscopy (TEM) and fluorescence were used to characterize formation of the supramolecular structures. Pyrene excimer formation observed by fluorescence demonstrated the encapsulation and aggregation of pyrene within the hydrophobic cores. In addition, peptide amphiphiles covalently functionalized with pyrene linked to the hydrophobic portion of the molecule exhibited excimer formation upon self-assembly into nanofibers. Interestingly excimer formation was not observed in similar molecules that formed spherical aggregates rather than cylindrical nanofibers.

Graphical abstract: Encapsulation of pyrene within self-assembled peptide amphiphile nanofibers

Back to tab navigation

Publication details

The article was received on 01 Jul 2005, accepted on 17 Aug 2005 and first published on 09 Sep 2005


Article type: Paper
DOI: 10.1039/B509246A
Citation: J. Mater. Chem., 2005,15, 4507-4512
  •   Request permissions

    Encapsulation of pyrene within self-assembled peptide amphiphile nanofibers

    M. O. Guler, R. C. Claussen and S. I. Stupp, J. Mater. Chem., 2005, 15, 4507
    DOI: 10.1039/B509246A

Search articles by author

Spotlight

Advertisements