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Issue 22, 2005
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The effect of amidic moieties on polysaccharides: evaluation of the physico-chemical and biological properties of amidic carboxymethylcellulose (CMCA) in the form of linear polymer and hydrogel

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Abstract

A new derivative of carboxymethylcellulose was synthesised by converting some of the carboxylic groups into amidic moieties (CMCA). The synthetic procedure allowed for a good control of the degree of substitution. The new polysaccharide was characterised in terms of physico-chemical properties and biocompatibility. It was also used for the realisation of a hydrogel, and its physico-chemical behaviour, such as water uptake and rheological parameters, were evaluated. The new CMCA hydrogel showed physico-chemical properties closer to those of Hyaluronan (Hyal) rather than native carboxymethylcellulose (CMC). Hydrogel cytotoxicity and biological activity were then comparatively investigated on osteoblast-like cells, taking into consideration the possible application of the hydrogel as a cell scaffold in orthopaedic tissue engineering. Finally, the effectiveness of cellular scaffolds for β-pancreatic islet cells was also studied.

Graphical abstract: The effect of amidic moieties on polysaccharides: evaluation of the physico-chemical and biological properties of amidic carboxymethylcellulose (CMCA) in the form of linear polymer and hydrogel

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Publication details

The article was received on 07 Mar 2005, accepted on 25 Apr 2005 and first published on 12 May 2005


Article type: Paper
DOI: 10.1039/B503399C
Citation: J. Mater. Chem., 2005,15, 2234-2241
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    The effect of amidic moieties on polysaccharides: evaluation of the physico-chemical and biological properties of amidic carboxymethylcellulose (CMCA) in the form of linear polymer and hydrogel

    R. Barbucci, G. Leone, M. Monici, D. Pantalone, M. Fini and R. Giardino, J. Mater. Chem., 2005, 15, 2234
    DOI: 10.1039/B503399C

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