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Issue 24, 2005
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Towards the rational design of MRI contrast agents: a practical approach to the synthesis of gadolinium complexes that exhibit optimal water exchange

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Abstract

The gadolinium(III) complex of S-SSSS-NO2BnDOTMA exhibits water exchange kinetics that are optimal for use in high relaxivity or targeted contrast agents. However, the synthesis of this ligand is hampered by the steric encumbrance imparted upon the cyclen ring by the nitrobenzyl substituent. A relatively simple modification has been used to enable the synthesis of larger quantities of a bifunctional ligand that retains similar fast water exchange properties. The gadolinium complex of S-SSS-NO2BnDO3MA-1A is shown to retain the rapid water exchange kinetics characteristic of a twisted square antiprismatic (TSAP) coordination geometry (τM = 6 ± 0.4 ns).

Graphical abstract: Towards the rational design of MRI contrast agents: a practical approach to the synthesis of gadolinium complexes that exhibit optimal water exchange

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Publication details

The article was received on 28 Jul 2005, accepted on 25 Aug 2005 and first published on 21 Sep 2005


Article type: Paper
DOI: 10.1039/B510778D
Citation: Dalton Trans., 2005, 3829-3837
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    Towards the rational design of MRI contrast agents: a practical approach to the synthesis of gadolinium complexes that exhibit optimal water exchange

    M. Woods, M. Botta, S. Avedano, J. Wang and A. D. Sherry, Dalton Trans., 2005, 3829
    DOI: 10.1039/B510778D

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