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Issue 21, 2005
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Molybdenum: biological activity and metabolism

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Molybdenum and tungsten are available to all organisms, with molybdenum having the far greater abundance and availability. Molybdenum occurs in a wide range of metalloenzymes in bacteria, fungi, algae, plants and animals, while tungsten was found to be essential only for a limited range of bacteria. In order to gain biological activity, molybdenum has to be complexed by a pterin compound, thus forming a molybdenum cofactor. In this article I will review the way that molybdenum takes from uptake into the cell, via formation of the molybdenum cofactor and its storage, to the final modification of molybdenum cofactor and its insertion into apo-metalloenzymes.

Graphical abstract: Molybdenum: biological activity and metabolism

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Publication details

The article was received on 19 Apr 2005, accepted on 16 Jun 2005 and first published on 26 Sep 2005

Article type: Perspective
DOI: 10.1039/B505527J
Citation: Dalton Trans., 2005, 3404-3409
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    Molybdenum: biological activity and metabolism

    R. R. Mendel, Dalton Trans., 2005, 3404
    DOI: 10.1039/B505527J

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