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Issue 2, 2005
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New C–N and C–C bond forming reactions catalyzed by titanium complexes

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Abstract

Titanium(IV) complexes with two basic dimethylamido ligands can be efficient catalysts for alkyne hydroamination by primary amines. Readily prepared pyrrolyl ligands have proven to be especially useful in generating active catalysts for hydroamination and hydrohydrazination. From these reactions, new methodologies for the synthesis of imines, hydrazones, α,β-unsaturated imines, pyridines, indoles, and pyrroles have developed. In addition, a new reaction that is mechanistically related to hydroamination, alkyne iminoamination, has been discovered. Iminoamination, which is a multicomponent coupling between an amine, alkyne, and isonitrile, provides unsymmetrical α,β-unsaturated β-iminoamines in a single, titanium-catalyzed step.

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Publication details

The article was received on 11 Oct 2004, accepted on 19 Nov 2004 and first published on 13 Dec 2004


Article type: Perspective
DOI: 10.1039/B415701J
Citation: Dalton Trans., 2005,0, 225-233
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    New C–N and C–C bond forming reactions catalyzed by titanium complexes

    A. L. Odom, Dalton Trans., 2005, 0, 225
    DOI: 10.1039/B415701J

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