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Issue 6, 2005
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Enantioselective C–C bond synthesis catalysed by enzymes

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Abstract

The enantioselective synthesis of C–C bonds is often the pivotal step of a synthesis. Nature has made a variety of versatile enzymes available that catalyse this type of reaction very selectively under mild conditions. Cyanohydrins, acyloins (α-hydroxy ketones), α-hydroxy acids and aldols (β-hydroxy ketones) are very efficiently synthesised enantioselectively with the aid of C–C bond forming enzymes, which we discuss in this tutorial review. In the case of the α-hydroxy acids the applications of nitrilases in a synthetic dkr even allows a disconnection that has no enantioselective chemical equivalent.

Graphical abstract: Enantioselective C–C bond synthesis catalysed by enzymes

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Publication details

The article was received on 12 Nov 2004 and first published on 02 Mar 2005


Article type: Tutorial Review
DOI: 10.1039/B412490A
Citation: Chem. Soc. Rev., 2005,34, 530-542
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    Enantioselective C–C bond synthesis catalysed by enzymes

    J. Sukumaran and U. Hanefeld, Chem. Soc. Rev., 2005, 34, 530
    DOI: 10.1039/B412490A

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