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Issue 6, 2005
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Metallacyclopeptides: Artificial analogues of naturally occurring peptides

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Abstract

Naturally occurring metalloproteins contain metal ions either to introduce a special reactivity or to stabilize a peptide structure. Since the early 1990s, chemists have been trying to use metal coordination for the fixation of short artificial peptides in well-defined cyclic structures. In this tutorial review a survey of the general approaches towards metallacyclopeptides as small cyclic peptide derivatives or as a part of a bigger α-helix (or β-sheet) structure is given. In three case studies it is shown how naturally occurring compounds can be mimicked by metal coordination to non-natural peptide derivatives.

Graphical abstract: Metallacyclopeptides: Artificial analogues of naturally occurring peptides

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Publication details

The article was received on 01 Feb 2005 and first published on 01 Mar 2005


Article type: Tutorial Review
DOI: 10.1039/B405660D
Citation: Chem. Soc. Rev., 2005,34, 496-506
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    Metallacyclopeptides: Artificial analogues of naturally occurring peptides

    M. Albrecht and P. Stortz, Chem. Soc. Rev., 2005, 34, 496
    DOI: 10.1039/B405660D

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