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Issue 6, 2005
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Chemical genetics to chemical genomics: small molecules offer big insights

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Abstract

Chemical genetics is the study of biological systems using small molecule (‘chemical’) intervention, instead of only genetic intervention. Cell-permeable and selective small molecules can be used to perturb protein function rapidly, reversibly and conditionally with temporal and quantitative control in any biological system. This tutorial review has been written to introduce this emerging field to a broad audience and focuses later on areas of biology where either it has made a significant impact, or it has the potential to do so: signalling, cytoskeleton, development, proteinprotein interactions and gene transcription.

Graphical abstract: Chemical genetics to chemical genomics: small molecules offer big insights

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Publication details

The article was received on 20 Sep 2004 and first published on 28 Feb 2005


Article type: Tutorial Review
DOI: 10.1039/B312875J
Citation: Chem. Soc. Rev., 2005,34, 472-482
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    Chemical genetics to chemical genomics: small molecules offer big insights

    D. R. Spring, Chem. Soc. Rev., 2005, 34, 472
    DOI: 10.1039/B312875J

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