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Issue 23, 2005
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Energy dissipation in slipping biological pumps

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Abstract

We describe active transport in slipping biological pumps, using mesoscopic nonequilibrium thermodynamics. The pump operation is characterised by its stochastic nature and energy dissipation. We show how heating as well as cooling effects can be associated with pump operation. We use as an example the well studied active transport of Ca2+ across a biological membrane by means of its ATPase, and use published data to find values for the transport coefficients of the pump under various conditions. Most of the transport coefficients of the pump, including those that relate ATP hydrolysis or synthesis to thermal effects, are estimated. This can give a quantitative description of thermogenesis. We show by calculation that all of these coupling coefficients are significant.

Graphical abstract: Energy dissipation in slipping biological pumps

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Publication details

The article was received on 23 Aug 2005, accepted on 21 Sep 2005 and first published on 07 Oct 2005


Article type: Paper
DOI: 10.1039/B511990A
Citation: Phys. Chem. Chem. Phys., 2005,7, 4009-4018
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    Energy dissipation in slipping biological pumps

    S. Kjelstrup, J. Miguel Rubi and D. Bedeaux, Phys. Chem. Chem. Phys., 2005, 7, 4009
    DOI: 10.1039/B511990A

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