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Issue 38, 2005
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Organometallic chemistry, biology and medicine: ruthenium arene anticancer complexes

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Abstract

Our work has shown that certain ruthenium(II) arene complexes exhibit promising anticancer activity in vitro and in vivo. The complexes are stable and water-soluble, and their frameworks provide considerable scope for optimising the design, both in terms of their biological activity and for minimising side-effects by variations in the arene and the other coordinated ligands. Initial studies on amino acids and nucleotides suggest that kinetic and thermodynamic control over a wide spectrum of reactions of Ru(II) arene complexes with biomolecules can be achieved. These Ru(II) arene complexes appear to have an altered profile of biological activity in comparison with metal-based anticancer complexes currently in clinical use or on clinical trial.

Graphical abstract: Organometallic chemistry, biology and medicine: ruthenium arene anticancer complexes

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Publication details

The article was received on 15 Jun 2005, accepted on 22 Jul 2005 and first published on 26 Aug 2005


Article type: Feature Article
DOI: 10.1039/B508531B
Citation: Chem. Commun., 2005, 4764-4776
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    Organometallic chemistry, biology and medicine: ruthenium arene anticancer complexes

    Y. K. Yan, M. Melchart, A. Habtemariam and P. J. Sadler, Chem. Commun., 2005, 4764
    DOI: 10.1039/B508531B

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