Issue 33, 2005
From the journal:

Chemical Communications

Simple iron-aminecatalysts for the cross-coupling of aryl Grignards with alkyl halides bearing β-hydrogens

Robin B. Bedford,*a   Duncan W. Bruce,b   Robert M. Frostc  and  Michael Hirdd  

* Corresponding authors

a School of Chemistry, University of Bristol, Cantock's Close, Bristol, UK
E-mail: r.bedford@bristol.ac.uk
Fax: +44 (0) 117 9251295

b Department of Chemistry, University of York, Heslington, York, UK

c Department of Chemistry, University of Exeter, Exeter, UK

d Kingston Chemicals, University of Hull, Cottingham Road, Kingston upon Hull, UK

Abstract

Mixtures of iron(III) chloride and appropriate amine ligands are active catalysts for the coupling of aryl Grignard reagents with primary and secondary alkyl halide substrates bearing β-hydrogens, under mild and simple reaction conditions.

Graphical abstract: Simple iron-amine catalysts for the cross-coupling of aryl Grignards with alkyl halides bearing β-hydrogens

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Article information

DOI
https://doi.org/10.1039/B507133J
Article type
Communication
Submitted
20 May 2005
Accepted
23 Jun 2005
First published
22 Jul 2005

Chem. Commun., 2005, 4161-4163

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Simple iron-amine catalysts for the cross-coupling of aryl Grignards with alkyl halides bearing β-hydrogens

R. B. Bedford, D. W. Bruce, R. M. Frost and M. Hird, Chem. Commun., 2005, 4161 DOI: 10.1039/B507133J

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