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Issue 28, 2005
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Towards the combinatorial synthesis of spongistatin fragment libraries by using asymmetric aldol reactions on solid support

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Abstract

By relying on asymmetric boron-mediated aldol reactions, solid phase methodology for the stereoselective synthesis of highly substituted spiroacetals was developed and applied to the preparation of a complex AB-spiroacetal subunit of the antimitotic agent spongistatin 1 (altohyrtin A).

Graphical abstract: Towards the combinatorial synthesis of spongistatin fragment libraries by using asymmetric aldol reactions on solid support

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Publication details

The article was received on 26 Apr 2005, accepted on 03 Jun 2005 and first published on 15 Jun 2005


Article type: Communication
DOI: 10.1039/B505746A
Citation: Chem. Commun., 2005, 3568-3570
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    Towards the combinatorial synthesis of spongistatin fragment libraries by using asymmetric aldol reactions on solid support

    I. Paterson, D. Gottschling and D. Menche, Chem. Commun., 2005, 3568
    DOI: 10.1039/B505746A

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