Issue 29, 2005
From the journal:

Chemical Communications

Enantioselective total synthesis of bioactive natural product (+)-Sch 642305: a structurally novel inhibitor of bacterial DNA primase and HIV-1 Tat transactivation†

Goverdhan Mehta*a  and  Harish M. Shindea  

* Corresponding authors

a Department of Organic Chemistry, Indian Institute of Science, Bangalore, India
E-mail: gm@orgchem.iisc.ernet.in
Fax: +91-80- 23600936
Tel: +91-80-22932850

Abstract

The total synthesis of the bioactive natural product (+)-Sch 642305 has been achieved from a readily available chiral building block using an RCM protocol to construct the key decalactone moiety; our approach is notable for its built-in flexibility and is diversity oriented.

Graphical abstract: Enantioselective total synthesis of bioactive natural product (+)-Sch 642305: a structurally novel inhibitor of bacterial DNA primase and HIV-1 Tat transactivation

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Article information

DOI
https://doi.org/10.1039/B505264E
Article type
Communication
Submitted
14 Apr 2005
Accepted
18 May 2005
First published
10 Jun 2005

Chem. Commun., 2005, 3703-3705

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Enantioselective total synthesis of bioactive natural product (+)-Sch 642305: a structurally novel inhibitor of bacterial DNA primase and HIV-1 Tat transactivation

G. Mehta and H. M. Shinde, Chem. Commun., 2005, 3703 DOI: 10.1039/B505264E

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