Superparamagnetic gadonanotubes are high-performance MRI contrast agents

Balaji Sitharaman; Kyle R. Kissell; Keith B. Hartman; Lesa A. Tran; Andrei Baikalov; Irene Rusakova; Yanyi Sun; Htet A. Khant; Steven J. Ludtke; Wah Chiu; Sabrina Laus; Éva Tóth; Lothar Helm; André E. Merbach; Lon J. Wilson

doi:10.1039/B504435A

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Chemical Communications

Issue 31, 2005

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Superparamagnetic gadonanotubes are high-performance MRI contrast agents

Balaji Sitharaman , Kyle R. Kissell , Keith B. Hartman , Lesa A. Tran , Andrei Baikalov , Irene Rusakova , Yanyi Sun , Htet A. Khant , Steven J. Ludtke , Wah Chiu , Sabrina Laus , Éva Tóth , Lothar Helm , André E. Merbach and Lon J. Wilson

Chem. Commun., 2005, 3915-3917

DOI: 10.1039/B504435A
Received 31 Mar 2005, Accepted 27 May 2005
First published on the web 08 Jul 2005

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We report the nanoscale loading and confinement of aquated Gd³⁺_n-ion clusters within ultra-short single-walled carbon nanotubes (US-tubes); these Gd³⁺_n@US-tube species are linear superparamagnetic molecular magnets with Magnetic Resonance Imaging (MRI) efficacies 40 to 90 times larger than any Gd³⁺-based contrast agent (CA) in current clinical use.

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Chemical Communications

Superparamagnetic gadonanotubes are high-performance MRI contrast agents

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