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Issue 25, 2005
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Enhanced relaxation of nanoparticle-bound supercoiled DNA in X-ray radiation

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Abstract

A therapeutic methodology was developed based on the large X-ray absorption cross-section of gold nanoparticles at high photon energies (>81 keV). Experimental results showed that the amounts of the relaxed circular supercoiled DNA (scDNA) for gold nanoparticle-bound scDNA were more than doubled compared to that for free scDNA under otherwise identical radiation conditions.

Graphical abstract: Enhanced relaxation of nanoparticle-bound supercoiled DNA in X-ray radiation

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Publication details

The article was received on 09 Mar 2005, accepted on 26 Apr 2005 and first published on 24 May 2005


Article type: Communication
DOI: 10.1039/B503425F
Citation: Chem. Commun., 2005, 3192-3194
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    Enhanced relaxation of nanoparticle-bound supercoiled DNA in X-ray radiation

    E. A. Foley, J. D. Carter, F. Shan and T. Guo, Chem. Commun., 2005, 3192
    DOI: 10.1039/B503425F

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