Issue 25, 2005
From the journal:

Chemical Communications

Enhanced relaxation of nanoparticle-bound supercoiled DNA in X-ray radiation†

Erika A. Foley,a   Joshua D. Carter,a   Fang Shana  and  Ting Guo*a  

* Corresponding authors

a Chemistry Department, One Shields Ave., University of California, Davis, USA
E-mail: tguo@ucdavis.edu
Fax: 530 752 8995
Tel: 530 754 5283;

Abstract

A therapeutic methodology was developed based on the large X-ray absorption cross-section of gold nanoparticles at high photon energies (>81 keV). Experimental results showed that the amounts of the relaxed circular supercoiled DNA (scDNA) for gold nanoparticle-bound scDNA were more than doubled compared to that for free scDNA under otherwise identical radiation conditions.

Graphical abstract: Enhanced relaxation of nanoparticle-bound supercoiled DNA in X-ray radiation

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Article information

DOI
https://doi.org/10.1039/B503425F
Article type
Communication
Submitted
09 Mar 2005
Accepted
26 Apr 2005
First published
24 May 2005

Chem. Commun., 2005, 3192-3194

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Enhanced relaxation of nanoparticle-bound supercoiled DNA in X-ray radiation

E. A. Foley, J. D. Carter, F. Shan and T. Guo, Chem. Commun., 2005, 3192 DOI: 10.1039/B503425F

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