Jump to main content
Jump to site search

Issue 20, 2005
Previous Article Next Article

Recognition of CG inversions in DNA triple helices by methylated 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues

Author affiliations

Abstract

Substituted 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues have been synthesised from 5-alkynyl-uridine derivatives, incorporated into triplex forming oligonucleotides (TFOs) and found to selectively bind CG inversions with enhanced affinity compared to T.

Graphical abstract: Recognition of CG inversions in DNA triple helices by methylated 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues

Back to tab navigation

Supplementary files

Publication details

The article was received on 16 Feb 2005, accepted on 01 Apr 2005 and first published on 14 Apr 2005


Article type: Communication
DOI: 10.1039/B502325D
Citation: Chem. Commun., 2005,0, 2555-2557
  •   Request permissions

    Recognition of CG inversions in DNA triple helices by methylated 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues

    R. T. Ranasinghe, D. A. Rusling, V. E. C. Powers, K. R. Fox and T. Brown, Chem. Commun., 2005, 0, 2555
    DOI: 10.1039/B502325D

Search articles by author

Spotlight

Advertisements