Issue 20, 2005
From the journal:

Chemical Communications

Enforcing solution phase nanoscopic aggregation in a palindromic tripeptide†

K. Krishna Prasad,a   C. S. Purohit,a   Alok Jain,b   R. Sankararamakrishnanb  and  Sandeep Verma*a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Technology-Kanpur, Kanpur-208016 (UP), India
E-mail: sverma@iitk.ac.in

b Department of Biological Sciences and Bioengineering, Indian Institute of Technology-Kanpur, Kanpur-208016 (UP), India

Abstract

C-terminal dimerization of a tripeptide palindrome afforded fibrillation in solution through an assembly probably driven by hydrogen bonding and hydrophobic contributions; such an approach provides an expeditious entry into fabrication of fibrillating peptides from non-fibrillating peptide sequences.

Graphical abstract: Enforcing solution phase nanoscopic aggregation in a palindromic tripeptide

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Article information

DOI
https://doi.org/10.1039/B500654F
Article type
Communication
Submitted
14 Jan 2005
Accepted
16 Feb 2005
First published
28 Feb 2005

Chem. Commun., 2005, 2564-2566

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Enforcing solution phase nanoscopic aggregation in a palindromic tripeptide

K. K. Prasad, C. S. Purohit, A. Jain, R. Sankararamakrishnan and S. Verma, Chem. Commun., 2005, 2564 DOI: 10.1039/B500654F

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