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Issue 15, 2005
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Expanding diversity in dynamic combinatorial libraries: simultaneous exchange of disulfide and thioester linkages

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Abstract

Dynamic combinatorial libraries have been prepared which feature two simultaneous covalent exchange reactions in aqueous solution at neutral pH. This allows for diversity, not only of the subunits that are linked, but also of the linkage itself.

Graphical abstract: Expanding diversity in dynamic combinatorial libraries: simultaneous exchange of disulfide and thioester linkages

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Publication details

The article was received on 14 Jan 2005, accepted on 09 Feb 2005 and first published on 18 Feb 2005


Article type: Communication
DOI: 10.1039/B500638D
Citation: Chem. Commun., 2005,0, 1959-1961
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    Expanding diversity in dynamic combinatorial libraries: simultaneous exchange of disulfide and thioester linkages

    J. Leclaire, L. Vial, S. Otto and J. K. M. Sanders, Chem. Commun., 2005, 0, 1959
    DOI: 10.1039/B500638D

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