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Issue 20, 2005
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Synthesis of constrained helical peptides by thioether ligation: application to analogs of gp41

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Abstract

We present a straightforward and high yielding method to synthesize constrained helical peptides via thioether ligation; this method represents an attractive alternative to the formation of lactam bridge constraints to induce helicity in peptides.

Graphical abstract: Synthesis of constrained helical peptides by thioether ligation: application to analogs of gp41

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Publication details

The article was received on 20 Dec 2004, accepted on 17 Feb 2005 and first published on 11 Mar 2005


Article type: Communication
DOI: 10.1039/B419015G
Citation: Chem. Commun., 2005,0, 2552-2554
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    Synthesis of constrained helical peptides by thioether ligation: application to analogs of gp41

    F. M. Brunel and P. E. Dawson, Chem. Commun., 2005, 0, 2552
    DOI: 10.1039/B419015G

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